In silico models complement and often reduce the need for physical experiments providing a level of flexibility and reproducibility not available in other screening technologies today. Researchers can now perform real-time in silico toxicity screening across a range of species, endpoints and targets on demand. Upon submission of a new compound, FUSION STS responds with a toxicity prediction, prediction confidence, a multiscale visual inventory of chemical descriptors, structural alerts, pathway involvement, and disease associations all live linked to the supporting literature. On-demand access to this diverse range of information will assist with mechanistic understanding and accelerate complex AOP studies. FUSION STS is redefining the impact statistical and mechanistic QSTR based systems are having on green chemical design, accelerated drug development, and safer food production.